Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Hemostasis01:05

Introduction to Hemostasis

13.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
13.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microfluidics-Enabled Nanoparticle for Multiscale Synergetic Osteoarthritis Therapy.

ACS nano·2026
Same author

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Modulating burn wound immunity and vasculature with a photo-crosslinkable glycyrrhizic acid-ginsenoside hydrogel.

Biomedical materials (Bristol, England)·2026
Same author

Mussel-inspired adhesive hydrogel reprograms osteoimmune niche for robust bone regeneration in complex defects.

Materials today. Bio·2026
Same author

A Novel Polyetheretherketone-Chondroitin Sulfate Zinc Composite: Enhancing Osseointegration through the Synergistic Effects of Chondroitin Sulfate and Zinc for Advanced Dental Implant Applications.

ACS biomaterials science & engineering·2026
Same author

Widefield in situ NV-MOKE microscopy for magnetometry.

The Review of scientific instruments·2025

Related Experiment Video

Updated: Jan 12, 2026

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

3.0K

Injectable Hydrogel Adhesive with Rapid In Situ Gelation and Robust Tissue Adhesion for Emergency Hemorrhage Control.

Yiqi Zeng1, Chao Xie2, Jingle Chen2

  • 1Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.

ACS Applied Materials & Interfaces
|November 5, 2025
PubMed
Summary

This study introduces a new biocompatible hydrogel adhesive that effectively stops severe bleeding. This advanced tissue adhesive shows strong wet adhesion and mechanical strength, offering a promising solution for trauma management.

Keywords:
emergency hemostasisin situ gelationinjectable hydrogellipoic acidwet tissue adhesion

More Related Videos

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

9.2K
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.6K

Related Experiment Videos

Last Updated: Jan 12, 2026

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde
07:04

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

3.0K
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

9.2K
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
08:40

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Published on: June 8, 2016

14.6K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Uncontrolled hemorrhage from severe trauma presents a significant clinical challenge.
  • Existing tissue adhesives often fail due to poor wet adhesion, slow bonding, and insufficient strength.

Purpose of the Study:

  • To develop an injectable, biocompatible hydrogel adhesive with enhanced hemostatic properties.
  • To improve wet adhesion, mechanical strength, and bonding kinetics for trauma applications.

Main Methods:

  • Synthesized a catalyst-free poly(disulfide) hydrogel network.
  • Incorporated melanin nanoparticles (CINP) to enhance cross-linking and properties.
  • Evaluated in vitro biocompatibility, tissue adhesion, and antibacterial activity.
  • Assessed hemostatic efficacy and intraorgan adhesion in animal models (liver, spleen, cardiac puncture).

Main Results:

  • The CINP-enhanced hydrogel (CINP@PolyLA-Ch) demonstrated superior wet adhesion and mechanical strength.
  • In vitro tests confirmed excellent biocompatibility and photoresponsive antibacterial properties.
  • Successful hemostasis and tissue adhesion were shown in various in vivo trauma models.

Conclusions:

  • The developed hydrogel adhesive offers a promising alternative to current hemostatic agents.
  • Its enhanced properties make it suitable for emergency management of massive hemorrhage.
  • Further research could lead to clinical applications in trauma care and surgery.