Related Experiment Video
Updated: Jan 12, 2026

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
Published on: November 1, 2019
Null models for comparing information decomposition across complex systems
Alberto Liardi1,2,3, Fernando E Rosas3,4,5,6, Robin L Carhart-Harris7
1Department of Computing, Imperial College London, London, United Kingdom.
Abstract:
A key feature of information theory is its universality, as it can be applied to study a broad variety of complex systems. However, many information-theoretic measures can vary significantly even across systems with similar properties, making normalisation techniques essential for allowing meaningful comparisons across datasets. Inspired by the framework of Partial Information Decomposition (PID), here we introduce Null Models for Information Theory (NuMIT), a null model-based non-linear normalisation procedure which improves upon standard entropy-based normalisation approaches and overcomes their limitations. We provide practical implementations of the technique for systems with different statistics, and showcase the method on synthetic models and on human neuroimaging data. Our results demonstrate that NuMIT provides a robust and reliable tool to characterise complex systems of interest, allowing cross-dataset comparisons and providing a meaningful significance test for PID analyses.
Related Concept Videos
Mechanistic Models: Overview of Compartment Models
Mechanistic Models: Compartment Models in Individual and Population Analysis
Multicompartment Models: Overview
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Classification of Systems-I
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:

