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Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

841
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Epilepsy and Seizures: Overview01:24

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Related Experiment Video

Updated: Jan 12, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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ECT for Catatonia in Schizencephaly.

Jennifer Puthota1, Andrew Francis2, Neel Madan3,4

  • 1Department of Psychiatry, Tufts Medical Center, Boston, MA.

The Journal of ECT
|November 5, 2025
PubMed
Summary

This case report details the successful electroconvulsive therapy (ECT) treatment for catatonia in a 51-year-old female with schizencephaly. This represents a novel approach for managing this rare brain malformation and its associated psychiatric conditions.

Keywords:
catatoniaelectroconvulsive therapyschizencephaly

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Area of Science:

  • Neurology
  • Psychiatry
  • Medical Genetics

Background:

  • Schizencephaly is a rare congenital brain malformation characterized by clefts in the cerebral cortex.
  • Associated medical comorbidities include neurological deficits, developmental delays, seizures, and psychiatric disorders.

Purpose of the Study:

  • To report the first known case of successful electroconvulsive therapy (ECT) for catatonia in a patient with schizencephaly.
  • To highlight the considerations for utilizing ECT in patients with this rare brain malformation.

Main Methods:

  • A case report of a 51-year-old female diagnosed with schizencephaly.
  • Description of the patient's development of catatonia and subsequent treatment with ECT.
  • Multidisciplinary approach involving neurology and internal medicine.

Main Results:

  • The patient with schizencephaly experienced successful treatment of catatonia using ECT.
  • The case demonstrates the feasibility and efficacy of ECT in this specific patient population.

Conclusions:

  • Electroconvulsive therapy (ECT) can be a safe and effective treatment for catatonia in individuals with schizencephaly.
  • A comprehensive risk-benefit analysis and a multidisciplinary team are crucial for managing ECT in patients with complex neurological conditions like schizencephaly.