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Related Experiment Video

Updated: May 1, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

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Published on: January 27, 2010

Sustained-release opioid following open abdominal urologic surgery A randomized, controlled study.

Natalie Vankka¹, Dylan Hollman¹, Sunita Ghosh²

¹Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada

|November 5, 2025

Summary

Short-term, low-dose, sustained-release hydromorphone did not improve early ambulation after urologic surgery compared to immediate-release hydromorphone alone. Pain scores and opioid consumption were similar between groups.

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Area of Science:

Anesthesiology
Pharmacology
Surgical Outcomes

Background:

Sustained-release opioids carry risks, yet their short-term use for acute pain in monitored settings lacks robust evidence.
Both immediate-release and sustained-release opioids are used for postoperative pain management.

Purpose of the Study:

To evaluate if short-term, low-dose sustained-release hydromorphone facilitates earlier ambulation post-urologic surgery compared to immediate-release hydromorphone alone.

Main Methods:

Randomized trial comparing sustained-release hydromorphone plus as-needed immediate-release hydromorphone versus as-needed immediate-release hydromorphone only.
Primary outcome: time to ambulate three steps after major open abdominal urologic surgery.

Main Results:

No significant difference in time to first mobilization, total opioid consumption, or pain scores between groups.
A trend towards increased nausea and sleep disturbance in the immediate-release group was not statistically significant.

Conclusions:

Short-term, low-dose sustained-release hydromorphone did not enhance early mobilization after major urologic surgery.
No significant differences in pain control or opioid use were observed between the two analgesic regimens.