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Material-driven nanoplatforms for precision hydrogen sulfide delivery.

Huiting Xu1, Yang Liu2, Tiandong Chen1

  • 1State Key Laboratory of Digital Medical Engineering, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, Jiangsu, 210096, PR China.

Redox Biology
|November 5, 2025
PubMed
Summary
This summary is machine-generated.

Hydrogen sulfide (H₂S), once toxic, is now a key signaling molecule. Precision delivery systems harness its dual roles for treating diseases like cancer and neurodegeneration.

Keywords:
Dual-concentration effectsGasotransmitterHydrogen sulfideTherapeutic nano-delivery

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Hydrogen sulfide (H₂S) is recognized as a crucial gaseous signaling molecule with dual roles in biological regulation and disease.
  • Enzymatic pathways (CBS, CSE, 3-MST) produce H₂S, influencing neuronal integrity, cardiovascular health, and metabolism.
  • H₂S exhibits protective functions at 10-100 μM, but imbalances are linked to pathologies.

Purpose of the Study:

  • To review advancements in precision-controlled H₂S modulation technologies.
  • To explore stimuli-responsive delivery systems for managing H₂S's concentration-dependent effects.
  • To discuss challenges and opportunities in optimizing H₂S therapeutics.

Main Methods:

  • Systematic analysis of current research on H₂S modulation technologies.
  • Examination of nanoscale delivery systems for targeted H₂S application.
  • Review of strategies for therapeutic window optimization and biosafety.

Main Results:

  • Emerging nanoscale systems offer enhanced spatiotemporal control for H₂S delivery.
  • These systems capitalize on H₂S's dichotomous bioactivities in managing diseases.
  • Progress has been made in resolving H₂S concentration-dependent paradoxes.

Conclusions:

  • Precision H₂S modulation holds significant clinical potential for various pathologies.
  • Nanoscale delivery systems are key to harnessing H₂S's therapeutic benefits.
  • Integrating material science and systems biology is crucial for future H₂S-based therapies.