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Updated: Jan 12, 2026

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

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Published on: February 21, 2015

Exploring hippocampal dysfunction in schizophrenia with pluripotent stem cell models.

¹Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NYC, NY, 10029, United States of America.

Schizophrenia Research

|November 5, 2025

Summary

This summary is machine-generated.

Human pluripotent stem cell-derived hippocampal organoids offer a novel in vitro model for studying schizophrenia. These models show promise for understanding neurodevelopmental origins and screening therapeutics for this complex brain disorder.

Keywords:

Cortex Genetics Neurodevelopment Organoids Stem cell biology hippocampus

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Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

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Published on: November 11, 2022

Area of Science:

Neuroscience
Stem Cell Biology
Psychiatric Research

Background:

Schizophrenia is a neurodevelopmental disorder impacting cognition and behavior, with hippocampal dysfunction implicated.
Traditional research models (animal, postmortem) have limitations in capturing human-specific and developmental aspects of schizophrenia.
Human pluripotent stem cell (hPSC)-derived brain organoids are emerging as powerful tools for studying psychiatric disorders.

Purpose of the Study:

To review the developmental basis of hippocampal dysfunction in schizophrenia.
To discuss the potential of hPSC-derived hippocampal organoids and assembloids for modeling schizophrenia.
To identify challenges and propose future directions for hippocampal organoid technology in schizophrenia research.

Main Methods:

Review of existing literature on hippocampal development and schizophrenia.
Analysis of studies utilizing hPSC-derived hippocampal organoids and assembloids.
Exploration of potential circuit modeling (DG-CA3, cortico-hippocampal, hippocampal-striatal).

Main Results:

Hippocampal organoid models are underdeveloped but show potential for studying schizophrenia.
Limited studies highlight the capacity to model specific hippocampal sub-circuits.
Key challenges include the lack of CA1/CA2 subfields, limited vascularization, and absence of microglia.

Conclusions:

hPSC-derived hippocampal organoids represent a promising, yet underutilized, platform for schizophrenia research.
Refining these models is crucial for mechanistic discovery and therapeutic screening.
Integrating genetic, imaging, and developmental data will advance understanding of schizophrenia's neurodevelopmental origins.