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Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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RIPK2/STAT3 signaling axis drives lung cancer metastasis through SNAIL activation: Molecular mechanisms and clinical

Wei Liu1, Peng Luo1, Xiaoliang Ji1

  • 1Department of Oncology, Cangzhou People's Hospital, 061500 Heibei, China.

Cellular Signalling
|November 5, 2025
PubMed
Abstract

Insights

Receptor-interacting protein kinase 2 (RIPK2) promotes lung adenocarcinoma metastasis by upregulating SNAIL via the RIPK2-STAT3 pathway. Targeting this axis may improve chemotherapy resistance and patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metastasis Research

Background:

  • Lung adenocarcinoma exhibits high metastatic potential, with epithelial-mesenchymal transition (EMT) being a key driver.
  • The precise molecular mechanisms governing EMT and metastasis in lung adenocarcinoma require further elucidation.

Purpose of the Study:

  • To investigate the role of Receptor-interacting protein kinase 2 (RIPK2) in the epithelial-mesenchymal transition (EMT) and metastasis of lung adenocarcinoma.
  • To elucidate the molecular pathway involving RIPK2 in lung adenocarcinoma progression.

Main Methods:

  • Analysis of TCGA database for RIPK2 expression and clinical correlation.
  • In vitro studies using RNA interference, overexpression, qRT-PCR, Western blot, co-immunoprecipitation, and immunofluorescence in lung adenocarcinoma cell lines.
  • In vivo validation of metastatic potential using tail vein injection in nude mice.

Main Results:

  • RIPK2 expression is elevated in lung adenocarcinoma and linked to poor prognosis.
  • RIPK2 promotes EMT, invasion, and metastasis; its nuclear localization enhances these effects and confers cisplatin resistance.
  • RIPK2 directly interacts with STAT3, leading to synergistic upregulation of SNAIL, a key EMT transcription factor.

Conclusions:

  • RIPK2, STAT3, and SNAIL form a critical signaling axis that drives EMT, invasion, metastasis, and chemotherapy resistance in lung adenocarcinoma.
  • The RIPK2-STAT3-SNAIL pathway presents a promising therapeutic target for lung adenocarcinoma treatment.
Keywords:
Epithelial-mesenchymal transitionLung adenocarcinomaMetastasis.RIPK2SNAIL

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