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Related Experiment Video

Updated: Jan 12, 2026

Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

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Accurate Single-Nanoparticle Sizing down to 3 nm with an Optofluidic Microcavity.

Shalom Palkhivala1, Larissa Kohler1, Christian Ritschel2

  • 1Karlsruher Institut für Technologie, Physikalisches Institut, Wolfgang-Gaede-Str. 1, Karlsruhe 76131, Germany.

ACS Nano
|November 5, 2025
PubMed
Summary

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We developed a new cavity-based sensing method for label-free nanoparticle detection. This technique accurately sizes single nanoparticles down to 3 nm, offering a powerful tool for advanced nanoparticle characterization.

Area of Science:

  • Nanoscience and nanotechnology
  • Analytical chemistry
  • Physical chemistry

Background:

  • Single-nanoparticle characterization is crucial for advanced applications.
  • Existing label-free detection methods often lack sufficient bandwidth or quantitative data.
  • There is a need for high-bandwidth, sensitive techniques for analyzing nanoparticle diffusion.

Purpose of the Study:

  • To present a cavity-based dispersive sensing method for label-free single-nanoparticle detection and sizing.
  • To achieve high bandwidth and sensitivity for capturing translational diffusion dynamics.
  • To enable quantitative analysis of single-particle properties, including size.

Main Methods:

  • Development of a cavity-based dispersive sensing platform.
Keywords:
Brownian motionautocorrelationgold nanoparticlesoptical microcavitysingle-particle detectionsizing

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  • Implementation of a standing-wave sensing geometry.
  • Creation of an analytical model for particle diffusion autocorrelation functions.
  • Methodology to handle transient single-particle signals.

    • Main Results:

    • Demonstration of label-free detection and sizing of single nanoparticles down to 3 nm in diameter.
    • Achieved high bandwidth to capture translational diffusion time scales.
    • Quantitative particle sizing with high precision and accuracy.

    Conclusions:

    • The developed cavity-based sensing method provides a sensitive and high-bandwidth tool for single-nanoparticle analysis.
    • This technique enables quantitative sizing and diffusion analysis of nanoparticles.
    • It represents a significant advancement in nanoparticle characterization.