[Fulminant streptococcal toxic shock syndrome developing under dasatinib therapy]
Miku Saito1, Yusuke Wada1, Ai Takahashi1
1Izumi City General Hospital Hematology/Nephrology.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|November 5, 2025
Summary
This study reports two cases of streptococcal toxic shock syndrome (STSS) in patients with chronic myeloid leukemia (CML) treated with dasatinib. The findings suggest a potential link between dasatinib therapy and the development of STSS in CML patients.
Area of Science:
- Hematology
- Oncology
- Infectious Diseases
Background:
- Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
- Dasatinib is a tyrosine kinase inhibitor used in CML treatment.
- Streptococcal toxic shock syndrome (STSS) is a severe, life-threatening condition.
Purpose of the Study:
- To investigate the potential association between dasatinib treatment and STSS in CML patients.
- To review CML treatment selection in patients who developed STSS.
Main Methods:
- Case report of two CML patients who developed STSS while on dasatinib.
- Literature review on CML treatment and STSS.
Main Results:
- Two CML patients treated with dasatinib developed STSS.
- Patient 1 experienced STSS after dose reduction of dasatinib.
- Patient 2 developed STSS after achieving deep molecular remission on dasatinib.
Conclusions:
- Dasatinib treatment may be associated with an increased risk of STSS in CML patients.
- Further investigation is warranted to confirm this association.
- Careful monitoring for STSS symptoms in CML patients on dasatinib is recommended.
Keywords:
Chronic myeloid leukemiaStreptococcal toxic shock syndromeTreatment free remissionTyrosine kinase inhibitorMore Related Videos
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