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Recurrent IgA1-λ-Type PGNMID Achieving Remission with Conventional Immunosuppressive Therapy
Kazuki Chida1, Atsushi Oura1, Tasuku Takahashi1
1Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Japan.
None:
A 58-year-old man was admitted to our hospital in April 2013 with elevated serum creatinine levels, proteinuria, and hematuria. A renal biopsy revealed membranoproliferative glomerulonephritis-like changes. Immunofluorescence showed IgA1 and λ light chain deposits along the capillary walls, confirming IgA-λ type proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Complete remission was achieved with glucocorticoid monotherapy in December 2013. After a relapse in April 2021, immunosuppressive treatment, including intravenous cyclophosphamide and subsequent mycophenolate mofetil, led to a complete remission. This case indicates that conventional immunosuppressive therapy may be effective for IgA-type PGNMID.
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