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Related Experiment Videos

Bone marrow lipofuscin.

K G Clark, W M Davidson

    Journal of Clinical Pathology
    |November 1, 1972
    PubMed
    Summary
    This summary is machine-generated.

    Lipofuscins, cellular pigments, are found in marrow macrophages and are not linked to aging. Their accumulation may indicate illness, differing from haemosiderin.

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    Area of Science:

    • Cellular Biology
    • Histopathology
    • Biochemistry

    Background:

    • Lipofuscins are pigment granules commonly found in macrophages within the bone marrow.
    • These pigments can be mistaken for haemosiderin in unstained samples.
    • Previous assumptions linked lipofuscin accumulation to senescence, but this is not supported by evidence.

    Purpose of the Study:

    • To investigate the nature and diagnostic significance of lipofuscins in bone marrow macrophages.
    • To differentiate lipofuscins from other cellular inclusions like haemosiderin.
    • To explore the relationship between lipofuscin presence and age or disease states.

    Main Methods:

    • Histological examination of bone marrow macrophages.
    • Distinguishing lipofuscins from haemosiderin using unstained preparations and fluorescence microscopy.

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  • Correlation of lipofuscin levels with patient age and clinical conditions (fever, leucocytosis).

    • Main Results:

    • Lipofuscins are readily distinguished from haemosiderin using fluorescence microscopy.
    • No correlation was found between lipofuscin accumulation and the age of individuals.
    • Elevated levels of lipofuscins were observed in conditions characterized by fever and leucocytosis.
    • The findings support the hypothesis that lipofuscins form from undigested cellular debris.

    Conclusions:

    • Lipofuscin accumulation in bone marrow macrophages is not indicative of aging.
    • The presence of large amounts of lipofuscin may serve as a biomarker for certain febrile illnesses with leucocytosis.
    • Sea-blue histiocytes likely represent macrophages heavily laden with lipofuscin granules.