Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

2.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.8K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

2.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
2.3K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

868
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
868
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

699
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
699
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

673
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
673
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

387
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
387

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-αvβ3 antibodies in FNAIT are associated with disturbed angiogenesis and intracranial hemorrhage in men and mice.

Blood·2026
Same author

Osteopontin in Atrial Fibrillation and Atrial Remodeling.

Journal of the American Heart Association·2026
Same author

Reversible Fibroblast Trajectories Regulated by MR Underlie Diastolic Dysfunction.

Circulation research·2026
Same author

Prognostic Value of High-sensitivity Troponin I for Cardiovascular Events in the Population of Kyrgyzstan.

Cardiovascular & hematological disorders drug targets·2026
Same author

The effect of mitoTEMPO on the development of hypoxia-induced pulmonary hypertension in male mice.

Physiological reports·2026
Same author

Aldosterone and the Mineralocorticoid Receptor in Atrial Fibrillation.

Hypertension (Dallas, Tex. : 1979)·2026

Related Experiment Video

Updated: Jan 12, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.6K

Central Obesity: An Emerging Player in Cardiac Remodelling and Dysfunction.

Kylychbek Suiunov1, Argen Mamazhakypov2, Andrey Polupanov3

  • 1International Medical Faculty, Osh State University, Osh, Kyrgyzstan.

Heart, Lung & Circulation
|November 5, 2025
PubMed
Summary

Central obesity, excess visceral fat even in normal weight individuals, significantly harms heart structure and function. This condition is a more reliable predictor of cardiac issues than body mass index.

Keywords:
Cardiac remodellingCentral obesityWaist circumferenceWaist-to-hip ratio

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.5K
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.9K

Related Experiment Videos

Last Updated: Jan 12, 2026

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.6K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.5K
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

6.9K

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Public Health

Background:

  • Obesity prevalence is rising globally, increasing cardiovascular disease risk.
  • Excess visceral fat (central obesity) is linked to adverse cardiovascular events and mortality, even in normal-weight individuals.
  • Central obesity negatively impacts cardiac structure and function.

Purpose of the Study:

  • To review current evidence on the detrimental effects of central obesity on cardiac function and structure.
  • To highlight central obesity as a critical factor in cardiovascular health.

Main Methods:

  • Literature review of population-based studies and research on central obesity measures.
  • Analysis of evidence linking central obesity indicators (waist circumference, waist-to-hip ratio, visceral adipose tissue) to cardiovascular outcomes.
  • Examination of studies comparing predictive power of central obesity measures versus body mass index for cardiac dysfunction.

Main Results:

  • Central obesity is associated with increased cardiovascular events and all-cause mortality.
  • Central obesity induces cardiac remodelling and dysfunction.
  • Measures of central obesity are more accurate predictors of cardiac remodelling and dysfunction than body mass index.

Conclusions:

  • Central obesity poses significant risks to cardiac structure and function.
  • Identifying and managing central obesity is crucial for cardiovascular disease prevention.
  • Further research into the mechanisms linking central obesity to cardiac pathology is warranted.