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Published on: July 14, 2016
Past shift work, melatonin receptor gene polymorphisms, and hyperhomocysteinemia among retired workers: The
Tingting Mo1, Weidong Zhang1, Yufei Wang1
1Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objectives:
This study aims to investigate the associations between past shift work and hyperhomocysteinemia and further explore the modification effects of MTNR1A rs12506228 and MTNR1B rs10830963 (2 single-nucleotide polymorphisms in melatonin receptor genes) on this association.
Methods:
Based on the data of 14,043 retirees from the Dongfeng-Tongji cohort, multivariate logistic regression was used to analyze the association between past shift work duration and hyperhomocysteinemia, and gene-environment interaction analysis was performed.
Results:
Among 14,043 retirees from the Dongfeng-Tongji cohort, we found that retirees with longer durations of past shift work were significantly associated with higher odds of hyperhomocysteinemia (odds ratio and 95% confidence interval for per 5-year increase: 1.04 [1.02-1.06], P<.001). Furthermore, MTNR1B rs10830963 significantly exacerbated the effect of long-duration past shift work on hyperhomocysteinemia odds (P-trend<.001, P-interaction=.01), and MTNR1A rs12506228 had a joint effect with past shift work on hyperhomocysteinemia odds (P-trend<.001, P-interaction=.89).
Conclusions:
The long-term hazard of shift work on hyperhomocysteinemia persisted from past to post retirement, and such association could be modified by MTNR1B rs10830963.
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