Response to "Looking Beyond Anxiety and Depression: Integrating Neurological Factors in Chronic Constipation"

Thank you for your insightful comments, which have expanded our research perspective from psychology to neural mechanisms. We agree that the core challenge of refractory constipation is closely related to neurological factors, and its essence lies in being a complex disorder involving sensory and neural dysregulation. Our preliminary fMRI studies have already identified abnormal functional connectivity in the brains of patients. Clinical observations suggest that different patient subtypes may correspond to distinct pathological mechanisms, necessitating differentiated diagnostic and therapeutic strategies. Future research will integrate psychological, neural, and physiological dimensions to construct a multidimensional pathological model.