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Phototherapy exposure variability in extremely preterm neonates due to different treatment protocols and devices:

Daniele De Luca1,2, Costanza Neri3, Vanessa Monin3

  • 1Physiopathology and Therapeutic Innovation INSERM-U999, Paris Saclay University, Paris, France. dm.deluca@icloud.com.

Journal of Perinatology : Official Journal of the California Perinatal Association
|November 5, 2025
PubMed

Insights

Phototherapy exposure in preterm infants varies significantly due to different treatment protocols and devices. This impacts both treatment duration and spectral power, highlighting the need for standardized approaches.

Area of Science:

  • Neonatal care
  • Pediatric phototherapy

Background:

  • Extremely preterm infants often require phototherapy for conditions like jaundice.
  • Variability in phototherapy protocols and devices may affect treatment efficacy and infant outcomes.

Purpose of the Study:

  • To investigate the variability of phototherapy exposure in extremely preterm infants.
  • To analyze differences in phototherapy duration and spectral power based on treatment protocols and devices.

Main Methods:

  • Cross-sectional observational study of 42 extremely preterm infants receiving light-emitting diode (LED) phototherapy.
  • Calculated phototherapy duration based on various expert guidelines.
  • Measured irradiance and estimated spectral power of LED devices.

Main Results:

  • Significant variation in phototherapy duration (0-72 hours) across different protocols (p < 0.001).
  • Substantial variation in spectral power (8.6-17.8 mW/nm) between LED devices (p < 0.001).
  • High median coefficients of variation observed for both duration (66.6%) and spectral power (18.1%).

Conclusions:

  • Phototherapy exposure in preterm infants is highly variable.
  • Differences in treatment protocols and LED devices contribute to significant variations in cumulative therapy duration and spectral power.
  • Standardization of phototherapy protocols and devices may be warranted to ensure consistent infant care.
Abstract

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