Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRE11 Deficiency Occurs in a Small Group of Cancers from Various Different Tumor Entities.

Diagnostics (Basel, Switzerland)·2026
Same author

Injury Profile in German Amateur Women's Football Is Knee-Centred and Match-Dominated: A Prospective One-Season Cohort Study.

Journal of clinical medicine·2026
Same author

Increased risk of postpartum hemorrhage in women with endometriosis and adenomyosis: a prospective cohort study.

Frontiers in endocrinology·2026
Same author

Superficial heat therapy in women's health.

Frontiers in medicine·2026
Same author

Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.

Briefings in bioinformatics·2026
Same author

Pain as an Exploratory Marker of Rehabilitation Engagement After ACL Reconstruction: Combined Ligament Injuries and Digital Disengagement in a Sensor-Based Monitoring Cohort.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Jan 12, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.7K

Quantitative Sensory Testing in Endometriosis Patients With Cyclic vs. Non-Cyclic Pain-A Case-Control Study.

Anna M Dückelmann1, Roman Rolke2, Katharina Möller3

  • 1Department of Obstetrics, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.

European Journal of Pain (London, England)
|November 5, 2025
PubMed
Summary

Endometriosis patients show significant pressure hyperalgesia, indicating peripheral sensitization as the main pain mechanism. This finding may guide future treatments targeting peripheral sensitization pathways.

Keywords:
QSTcyclic painendometriosismixed‐painneuropathicnociceptivenon‐cyclic painpainpelvic painquantitative sensory testing

More Related Videos

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

16.4K
Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

17.4K

Related Experiment Videos

Last Updated: Jan 12, 2026

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.7K
Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

16.4K
Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

17.4K

Area of Science:

  • Neuroscience
  • Pain Research
  • Gynecology

Background:

  • Endometriosis is a chronic inflammatory disease causing significant pain in women.
  • Pain can be cyclic (menstrual) or persistent non-cyclic.
  • Understanding pain mechanisms is crucial for effective treatment.

Purpose of the Study:

  • To compare the somatosensory profile of endometriosis patients with healthy controls.
  • To differentiate profiles between cyclic and non-cyclic endometriosis pain subtypes.
  • To identify markers of peripheral or central nervous sensitization in endometriosis.

Main Methods:

  • Utilized quantitative sensory testing (QST) following a standardized protocol.
  • Compared QST results between endometriosis patients (cyclic and non-cyclic) and healthy controls.
  • Assessed somatosensory alterations in affected and remote body areas.

Main Results:

  • Endometriosis patients exhibited significant hyperalgesia to cold and blunt pressure, most pronounced in non-cyclic cases.
  • Massive pressure hyperalgesia was observed in all patients in the lower abdomen.
  • Non-nociceptive somatosensory loss (thermal and tactile) was also noted, with some overlap in remote areas.

Conclusions:

  • Endometriosis-related hyperalgesia is primarily driven by peripheral sensitization.
  • Primary afferent sensitization likely facilitates pain transmission in endometriosis.
  • Findings suggest targeting peripheral sensitization mechanisms for future endometriosis treatments.