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Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

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Cellular senescence and cell therapy in cardiovascular diseases

Dehua Chang1, Jiaqi Wang2, Shuoji Zhu3,4

  • 1Department of Cardiovascular Surgery, Regenerative Medicine Research on the treatment of Mesenchymal Stem Cells, University of Tokyo Hospital, Tokyo, 113-8654, Japan. dehua_chang@yahoo.com.

Stem Cell Research & Therapy
|November 5, 2025
PubMed

Insights

Population aging accelerates cardiovascular diseases through cellular senescence. Regenerative medicine offers promising therapies for age-related heart conditions.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Regenerative Medicine

Background:

  • Population aging is a global challenge, with significant cardiovascular health implications.
  • Cellular senescence, characterized by telomere shortening, oxidative stress, and DNA damage, contributes to cardiovascular diseases like atherosclerosis, myocardial infarction, pulmonary hypertension, and heart failure.
  • Senescent cells, including cardiomyocytes, endothelial cells, fibroblasts, and vascular smooth muscle cells, play a crucial role in cardiovascular aging.

Purpose of the Study:

  • To review the current understanding of cellular senescence in cardiovascular aging.
  • To discuss molecular and cellular mechanisms underlying cardiovascular aging.
  • To highlight potential therapeutic targets and the promise of regenerative medicine for cardiovascular aging.

Main Methods:

  • Literature review of molecular and cellular processes in cardiovascular aging.
  • Analysis of biomarkers for senescent cells (e.g., p53, p21, p16Ink4a, SA-β-gal).
  • Examination of signaling pathways (e.g., Akt, AMPK) involved in cardiovascular aging.

Main Results:

  • Cellular senescence contributes to various cardiovascular diseases through mechanisms like telomere shortening, oxidative stress, and mitochondrial dysfunction.
  • Specific molecules (p53, p21, p16Ink4a) and markers (SA-β-gal) are indicative of senescent cells.
  • Factors like Akt and AMPK signaling pathways are implicated in cardiovascular aging.

Conclusions:

  • Cellular senescence is a key driver of age-related cardiovascular diseases.
  • Understanding these mechanisms provides targets for therapeutic interventions.
  • Regenerative medicine, utilizing mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs), shows significant potential for treating cardiovascular aging.

Keywords:
Cardiac agingCardiovascular diseasesCellular senescenceMSCiPSC

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