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Virtual Reality Is Safe and Can Reduce In-Hospital Anxiety and Pain: A Systematic Review With Meta-Analyses and Trial
Karsten L Lassen1,2, Kristian Hermander3,4, Pether Jildenstål1,3,4,5,6,7
1Department of Health Sciences, Lund University, Lund, Sweden.
European Journal of Pain (London, England)
|November 5, 2025
Summary
Virtual reality (VR) significantly reduces patient anxiety and pain during hospital procedures. This non-pharmacological intervention offers a safe option with minimal side effects, improving recovery times.
Area of Science:
- Medical technology
- Surgical innovation
- Patient care
Background:
- Virtual reality (VR) is increasingly used in hospitals for surgical procedures.
- The impact of VR on patient outcomes remains unclear.
- This review focuses on VR's effect on adult patients undergoing elective surgery.
Purpose of the Study:
- To systematically review the impact of virtual reality (VR) on adult patients undergoing elective surgical procedures.
- To assess VR's effectiveness in improving patient outcomes.
- To evaluate VR as a non-pharmacological intervention in surgical settings.
Main Methods:
- Searched CENTRAL, MEDLINE, EMBASE, and CINAHL databases for studies published after 2017.
- Assessed risk of bias using ROB2 and ROBINS-I.
- Performed meta-analyses, Trial Sequential Analyses, and GRADE evaluation for randomized controlled trials.
Main Results:
- Included 37 studies (3152 patients).
- VR significantly reduced anxiety (p<0.0001) and pain (p<0.00005).
- Observed shorter recovery times; adverse events were mild and infrequent.
Conclusions:
- Virtual reality effectively reduces pain and anxiety in hospitalized adult surgical patients.
- VR is a safe adjunct to standard care with minimal side effects.
- Further standardized, high-quality trials are needed due to outcome heterogeneity and bias risk.

