Association between non-HDL-C/HDL-C ratio and sarcopenia in US adults: a population-based study

Area of Science:

• Cardiovascular Health
• Gerontology
• Metabolic Syndrome

Background:

• The non-HDL-C/HDL-C ratio (NHHR) is a key lipid biomarker reflecting lipoprotein balance.
• Limited research exists on the NHHR's impact on sarcopenia.
• This study investigates the association between NHHR and sarcopenia risk.

Purpose of the Study:

• To examine the correlation between serum NHHR levels and the risk of sarcopenia.
• To assess the NHHR as a potential biomarker for sarcopenia management and prediction.

Main Methods:

• Utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2011-2018.
• Employed multivariable logistic regression to analyze the NHHR-sarcopenia relationship.
• Conducted subgroup, sensitivity, and restricted cubic spline analyses to ensure robustness and explore nonlinearity.

Main Results:

• Included 5,491 participants; 6.68% had sarcopenia.
• Elevated NHHR showed a significant positive correlation with sarcopenia incidence (OR=1.13).
• The highest NHHR quartile group had 2.11 times higher sarcopenia occurrence than the lowest.

Conclusions:

• NHHR is associated with an elevated risk of sarcopenia in the U.S. adult population.
• NHHR may serve as a valuable biomarker for sarcopenia risk assessment.
• Further research could explore NHHR's role in clinical sarcopenia management strategies.