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Data-Based Method to Reduce Unnecessary Autopsies in Suspected Overdose Deaths.
Nicole D'Anna1, Megan Brown1, Alex K Williamson1,2
1Office of Chief Medical Examiner.
The American Journal of Forensic Medicine and Pathology
|November 6, 2025
Summary
The New York City Office of Chief Medical Examiner (OCME) can reduce autopsies for suspected opioid overdose deaths by 32.8% using a toxicology-focused approach (View-Tox). This method accurately certifies most cases without full autopsy, easing the burden on forensic pathologists.
Area of Science:
- Forensic Pathology
- Toxicology
- Public Health
Background:
- The opioid overdose crisis significantly impacts medical examiner offices, leading to an overwhelming number of cases.
- A national shortage of forensic pathologists makes it challenging to perform autopsies on all suspected overdose deaths as recommended.
- The New York City Office of Chief Medical Examiner (OCME) faces severe strain due to over 3000 overdose deaths in 2022.
Purpose of the Study:
- To assess the feasibility of certifying suspected overdose deaths using a limited approach (View-Tox) instead of full autopsies.
- To determine the accuracy of certifying deaths based on history, external examination, and toxicology testing.
- To evaluate the potential reduction in autopsy workload for the OCME.
Main Methods:
- Utilized the Suspected Deaths (SPOT) database from the OCME Drug Intelligence and Intervention Group (DIIG).
- Applied six exclusionary criteria to identify cases eligible for the View-Tox approach.
- Cases were evaluated based on known history, circumstances, external examination, and toxicology results.
Main Results:
- The View-Tox eligibility criteria successfully excluded homicides, suicides, non-overdose accidents, and most undetermined manner deaths.
- Among eligible cases, 99.2% were accurately certified using toxicology results and pre-autopsy information alone.
- Implementing this approach could have reduced autopsies for suspected overdose deaths at OCME by 32.8% in 2022.
Conclusions:
- A View-Tox approach, focusing on toxicology and available information, is highly accurate for certifying many suspected overdose deaths.
- This strategy can significantly decrease the autopsy burden on medical examiner offices during public health crises.
- The findings support a more efficient case management system for overdose deaths, preserving resources and addressing pathologist shortages.

