The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review
Li Cao1, Biao Deng1, Xiaole Wang2
1Jiangxi University of Chinese Medicine, Nanchang, Jiangxi Province, China.
Brain and Behavior
|November 6, 2025
Summary
Low back pain (LBP) and depression share an interdependent relationship, with shared brain regions and psychological factors contributing to their connection. Effective management requires addressing both physical and mental health through interdisciplinary approaches.
Area of Science:
- Neuroscience
- Psychology
- Public Health
Background:
- Low back pain (LBP) and depression are highly prevalent conditions.
- Understanding the interplay between LBP and depression is critical for effective treatment strategies.
Purpose of the Study:
- To explore the potential relationship between low back pain and depression.
- To elucidate the biological, psychological, and social factors contributing to this relationship.
Main Methods:
- Literature review of existing research on low back pain and depression.
- Examination of studies investigating the neurobiological, psychological, and social links.
Main Results:
- An interdependent relationship exists between LBP and depression.
- Chronic pain can precipitate depression; depression can intensify pain perception.
- Shared brain regions for pain and emotional regulation suggest a neurobiological basis.
- Psychological factors like anxiety and stress are associated with both conditions.
Conclusions:
- The LBP-depression relationship is complex and multifaceted.
- Effective management necessitates addressing both physical pain and psychological distress.
- Interdisciplinary approaches including pharmacological, psychological, and physical therapies are recommended.
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