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Related Experiment Video

Updated: Jan 12, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Radiotherapy for Keloids: A Comprehensive Narrative Review.

Hsin-Hua Nien1, Pei-Chieh Yu1, Yu-Hsiu Yen2

  • 1Department of Radiation Oncology, Cathay General Hospital, Taipei, TWN.

Cureus
|November 6, 2025
PubMed
Summary

Surgical excision combined with radiotherapy effectively reduces keloid recurrence. This review details various radiotherapy methods for keloid management, aiding treatment strategy development.

Keywords:
brachytherapyelectronexternal beam radiotherapykeloidphotonradiotherapy

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Area of Science:

  • Dermatology
  • Radiation Oncology

Background:

  • Keloids cause significant discomfort and impact daily life.
  • Monotherapy for keloids often yields unsatisfactory results.
  • Surgical excision with adjuvant radiotherapy is a promising approach to reduce keloid recurrence.

Purpose of the Study:

  • To provide a narrative overview of radiation modalities for keloid management.
  • To summarize clinical evidence supporting the efficacy of different radiotherapy techniques.
  • To analyze factors influencing treatment outcomes and adverse effects.

Main Methods:

  • Literature review of studies on radiotherapy for keloid treatment.
  • Summarization of radiation treatment regimens, recurrence rates, and adverse effects by modality.
  • Analysis of factors affecting treatment efficacy.

Main Results:

  • Various radiation modalities and sources exist, each with unique properties and setup requirements.
  • Clinical outcomes and adverse effects vary across studies and treatment parameters.
  • Adjuvant radiotherapy following surgical excision demonstrates reduced keloid recurrence rates.

Conclusions:

  • A comprehensive understanding of radiation modality characteristics is crucial for developing tailored treatment strategies.
  • Institution-specific approaches, supported by multidisciplinary collaboration, can optimize keloid management.
  • Careful planning and delivery of radiotherapy alongside surgery can lead to favorable patient outcomes.