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Related Experiment Video

Updated: Jan 12, 2026

Clinical Application of Microscope-Assisted Minimally Invasive Anterior Lumbar Interbody Fusion
04:42

Clinical Application of Microscope-Assisted Minimally Invasive Anterior Lumbar Interbody Fusion

Published on: June 16, 2023

953

Postoperative Decrease in Volumetric Bone Mineral Density in Patients Undergoing Anterior or Lateral Lumbar Interbody

Koki Tsuchiya1,2, Ichiro Okano1,2, Ali E Guven1

  • 1Spine Care Institute, Hospital for Special Surgery, New York, NY, USA.

HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery
|November 6, 2025
PubMed
Summary

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Articles linked to this work by shared authors, journal, and citation graph.

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Streamlining the MRI-Derived Vertebral Bone Quality Score for Preoperative Osteoporosis and Osteopenia Screening.

Global spine journal·2026
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Diagnostic Value of Upright-Supine Imaging and Its Association with Postoperative Outcomes in Degenerative Lumbar Spondylolisthesis - A Two-Year PROM Based Comparison with Flexion Extension Radiographs.

The spine journal : official journal of the North American Spine Society·2026
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What are the Optimal Age Thresholds for qCT-based Osteoporosis and Osteopenia Screening in Patients Undergoing Lumbar Fusion Surgery?

Spine·2026
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GLP-1 Agonist Use Is Not Associated With a Reduction of Paraspinal Muscle Quality in Diabetic Patients With Low Back Pain: A Retrospective Cohort Study.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery·2026
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Effects of Topical Steroids on Postoperative Pain in Patients Undergoing Stand-Alone Lateral Lumbar Interbody Fusion.

Cureus·2026
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Multimodal Imaging Predictors of FEA-Derived Lumbar Vertebral Compression Strength.

Spine·2026

Lateral lumbar interbody fusion (LIF) surgery can lead to bone loss in adjacent vertebrae. However, stand-alone LIF and 360° constructs showed similar bone loss, indicating invasiveness may not worsen outcomes.

Area of Science:

  • Spine Surgery
  • Orthopedics
  • Radiology

Background:

  • Spine surgery is linked to bone loss, but the impact of lateral lumbar interbody fusion (LIF) is not well understood.
  • Quantitative computed tomography (QCT) is used to assess bone density changes after spinal procedures.

Purpose of the Study:

  • To investigate the effect of LIF on adjacent vertebrae bone loss using QCT.
  • To compare bone loss between stand-alone LIF (SA-LIF) and 360° constructs (LIF with posterior fixation).

Main Methods:

  • Retrospective review of 72 patients undergoing SA-LIF or 360° constructs between 2016-2024.
  • Volumetric bone mineral density (vBMD) of adjacent vertebrae (UV+1, UV+2, LV-1) measured via QCT 2-12 months post-surgery.
  • Comparison of pre- and postoperative vBMD and between surgical groups, adjusted for age.
Keywords:
lumbar spineosteoporosisoutcomesquantitative computed tomographyspine

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Last Updated: Jan 12, 2026

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Published on: June 16, 2023

953
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Main Results:

  • Both SA-LIF and 360° constructs led to significant vBMD decreases in adjacent vertebrae.
  • SA-LIF showed decreases at UV+1 and UV+2; 360° constructs showed decreases at UV+2 and LV-1.
  • No significant difference in the percentage of vBMD change was found between the SA-LIF and 360° groups.

Conclusions:

  • Both SA-LIF and 360° construct surgeries negatively impact adjacent vertebral bone density postoperatively.
  • The additional invasiveness of posterior fixation in 360° constructs did not result in significantly greater bone loss compared to SA-LIF.
  • These findings suggest that the extent of bone loss may be similar regardless of the type of LIF construct used.