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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

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Characterising negative symptoms in schizophrenia: CHANSS study protocol.

Noham Wolpe^1,2, Clàudia Aymerich^3,4,5, Ying Jin⁶

¹Department of Physical Therapy, The Stanley Steyer School of Health Professions, Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.

|November 6, 2025

Summary

The CHANSS study investigates cognitive mechanisms behind negative symptoms in schizophrenia, focusing on motivation deficits. Findings aim to enable personalized treatments for schizophrenia patients with motivational impairments.

Keywords:

Apathy cognition computational modelling motivation negative symptoms

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Area of Science:

Neuroscience
Psychiatry
Cognitive Psychology

Background:

Negative symptoms, especially motivational deficits, significantly hinder schizophrenia recovery and functional outcomes.
Current interventions inadequately address these profound challenges.
Understanding the cognitive underpinnings of motivational deficits is crucial for advancing schizophrenia treatment.

Purpose of the Study:

The CHANSS study aims to dissect cognitive mechanisms underlying motivational impairments in schizophrenia.
It focuses on executive cognition, motivational cognition, and meta-cognition.
The goal is to identify distinct cognitive and behavioral subtypes of motivational dysfunction.

Main Methods:

A large, international, cross-sectional study involving diverse schizophrenia patient groups.
Utilizes a comprehensive cognitive battery, clinical scales, self-report measures, and novel computerized tasks.
Assesses option generation, reward-based decision-making, risk sensitivity, and performance self-evaluation, controlling for confounding factors.

Main Results:

The study tests if specific patient profiles show distinct cognitive domain impairments affecting goal-directed behavior.
Explores hierarchical relationships between cognitive processes and their impact on motivation and self-evaluation.
Aims to reveal how neurocognitive deficits cascade to impair motivated behavior.

Conclusions:

CHANSS seeks to deepen the mechanistic understanding of motivational deficits in schizophrenia.
Findings are expected to inform personalized, targeted interventions and future clinical trials.
The study promotes a shift towards stratified treatment strategies for schizophrenia.