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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation
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Fibroids and pregnancy.

Diana Ramasauskaite1, Nikhil Purandare2, Ivonne Diaz3

  • 1Clinic of Obstetrics and Gynecology, Vilnius University Faculty of Medicine, Vilnius, Lithuania.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|November 6, 2025
PubMed
Summary
This summary is machine-generated.

Uterine fibroids affect 1.6–10.7% of pregnancies, usually without complications. However, larger or multiple fibroids increase risks like preterm birth and postpartum hemorrhage, necessitating careful management.

Keywords:
complicationsfibroidsleiomyomamanagementpregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Medicine

Background:

  • Uterine fibroids (leiomyomas) are common, affecting 1.6% to 10.7% of pregnancies.
  • While often asymptomatic, fibroids can lead to complications, particularly when multiple, large (>5 cm), or located in the lower uterine segment.

Purpose of the Study:

  • To review the prevalence, potential complications, and outcomes of pregnancies complicated by uterine fibroids.
  • To summarize current data on obstetric risks associated with uterine fibroids.

Main Methods:

  • Literature review of studies investigating uterine fibroids in pregnancy.
  • Analysis of reported obstetric complications and outcomes.

Main Results:

  • 10-30% of pregnant women with fibroids experience complications.
  • Common complications include red degeneration (8%), preterm birth (OR 1.5), malpresentation (OR 2.65), placental abruption (OR 2.63), placenta previa (OR 2.21), cesarean birth (OR 2.60), and postpartum hemorrhage (OR 2.95).
  • Most women deliver vaginally; cesarean delivery is for standard obstetric indications.

Conclusions:

  • Pregnancies with uterine fibroids are generally safe, but specific fibroid characteristics increase complication risks.
  • Cesarean myomectomy during delivery is generally discouraged.
  • Further high-quality research is needed to fully elucidate fibroid impact on pregnancy outcomes.