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  3. Programmable Anisotropic Hydrogels For Biomedicine: From Precise Design To Advanced Applications.
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  3. Programmable Anisotropic Hydrogels For Biomedicine: From Precise Design To Advanced Applications.

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Programmable Anisotropic Hydrogels for Biomedicine: From Precise Design to Advanced Applications.

Fengli Zhang1,2, Zijian Gao1, Lushan Sun1,2

  • 1Institute of Petrochemical Technology, Jilin Institute of Chemical Technology, Jilin 132022, China.

ACS Applied Materials & Interfaces
|November 6, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Anisotropic hydrogels offer unique direction-dependent properties for biomedical uses. This review covers their design, fabrication, and applications in tissue engineering and drug delivery, highlighting future potential.

Keywords:
anisotropic hydrogelbiocompatibilitybiomedicalhealth monitoringtissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Anisotropic hydrogels possess directionally dependent properties, making them promising for biomedical applications.
  • Their unique characteristics stem from controlled structural anisotropy.

Purpose of the Study:

  • To review recent advancements in the design, fabrication, and applications of biomedical anisotropic hydrogels.
  • To analyze materials, preparation techniques, characterization methods, and responsiveness of these hydrogels.

Main Methods:

  • Systematic analysis of natural and synthetic polymer matrices (chitosan, alginate, polyacrylamide).
  • Evaluation of fabrication techniques: template-directed synthesis, external field methods, 3D printing.
  • Discussion of characterization methods: microscopy, rheology, biosafety assessments.

Main Results:

  • Tailored mechanical, electrical, and biocompatible properties achieved through material selection and fabrication.
  • Precise engineering of anisotropic microstructures is possible with advanced techniques.
  • Intelligent responsiveness to stimuli (light, temperature, pH) demonstrated.

Conclusions:

  • Anisotropic hydrogels show significant potential in tissue engineering, drug delivery, wound dressing, and health monitoring.
  • Interdisciplinary collaboration is crucial for advancing these hydrogels toward clinical translation.
  • Future research should address current challenges to unlock full biomedical potential.