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Mitigating End-Stage Fatigue: Acute Inhaled Salmeterol Preserves Sprint Power in Simulated Cycling.

Michele Merlini1, Walter Staiano2,3, Luca Angius4

  • 1School of Natural Sciences, University of Kent, Canterbury, UK.

Scandinavian Journal of Medicine & Science in Sports
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Summary

A single 100 μg dose of salmeterol, an inhaled bronchodilator, reduced muscle fatigue and improved sprint performance in elite cyclists after a simulated race. This challenges previous assumptions about salmeterol

Keywords:
WADAdopingdurabilityelite sportergogenic aidphysiological resilienceβ2‐agonists

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Area of Science:

  • Sports Medicine
  • Exercise Physiology
  • Pharmacology

Background:

  • Salmeterol is a long-acting beta-agonist bronchodilator.
  • Its effects on sprint performance in non-asthmatic athletes are not well-established.
  • Elite road cyclists rely on late-race sprint performance.

Purpose of the Study:

  • To investigate the effect of a single inhaled dose of salmeterol on 12-s sprint performance in elite road cyclists.
  • To assess performance in both fresh and fatigued states after a simulated race.
  • To determine if salmeterol impacts physiological markers of fatigue.

Main Methods:

  • Randomized crossover design with 16 elite male cyclists.
  • Participants inhaled 100 μg salmeterol or placebo 1 hour before testing.
  • Trials included a fresh sprint, a 1-hour simulated race, and a fatigued sprint, with power output and myoelectric activity measured.

Main Results:

  • Salmeterol attenuated the decline in peak and mean power after the simulated race.
  • Fatigued sprint peak power was significantly higher with salmeterol compared to placebo.
  • No significant effects were observed on fresh sprint performance or myoelectric activity.

Conclusions:

  • Acute inhalation of salmeterol can reduce muscle fatigue and enhance sprint performance in cyclists at the end of a simulated race.
  • These findings suggest a potential performance-enhancing effect of therapeutic doses of inhaled salmeterol in competitive cycling.
  • The results challenge the established view that inhaled salmeterol has no ergogenic effect in this population.