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Changing Trends in Bladder Cancer Epidemiology in the Israeli Population: 1996-2016.
Nicole Taylor1, Gabriel Heering1, Oded Icht2
1Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
The Israel Medical Association Journal : IMAJ
|November 6, 2025
Summary
Bladder cancer (BC) incidence in Israel shows rising in situ rates and decreasing invasive rates over two decades. These trends, mirroring lung cancer, may impact screening guidelines and healthcare planning for bladder cancer.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Bladder cancer (BC) incidence is increasing globally and is a significant concern in Israeli males.
- Observed variations in BC incidence across different populations necessitate detailed epidemiological analysis.
Purpose of the Study:
- To analyze temporal trends and the epidemiological profile of bladder cancer (BC) in Israel.
- To investigate BC incidence patterns across diverse demographic groups within Israel.
Main Methods:
- Utilized data from the Israeli National Cancer Registry (1996-2016) for all diagnosed bladder cancer (BC) cases.
- Calculated age-standardized rates and employed Joinpoint regression analysis to determine annual percent change (APC) in incidence.
Main Results:
- Between 1996-2016, 28,953 BC cases were recorded in Israel.
- In situ BC rates significantly increased for both Jewish and Arab males (APC > 16.76, P < 0.05).
- Invasive BC incidence declined in Jewish males (APC = -7.6, P < 0.05) and Arab males (APC = -12.0, P < 0.05) during specific periods.
Conclusions:
- The past two decades show a rise in in situ BC and a decrease in invasive BC rates.
- Bladder cancer (BC) epidemiological trends align with lung cancer, likely due to shared risk factors like smoking.
- These findings are crucial for refining clinical guidelines for screening and informing healthcare planning for bladder cancer.
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