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Transient global amnesia
Aleksandra Kamila Galwa-Støkkan1, Ingunn Egeberg Vari2, Mikkel Elvebakk Saidi2
1Kavli-instituttet for systemnevrovitenskap, NTNU, og, Nevroklinikken, St. Olavs hospital.
Abstract:
Transient global amnesia is an acute and temporary failure of the ability to form new memories. The underlying mechanism is not fully understood but is thought to involve dysfunction of the hippocampus, particularly Cornu Ammonis 1 (CA1). Traditionally, the condition has been regarded as rare, isolated and fully reversible, but recent data suggest a more complex symptom profile. The diagnosis is still based on criteria from 1990, established before high-field MRI was widely available. Although the diagnosis is clinical, MRI can provide important clarification for both differential diagnosis and therapeutic decision-making. This clinical review discusses the functional neuroanatomy of the memory system, possible pathophysiological mechanisms and diagnostic aspects of transient global amnesia.
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