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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

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Radiological Patterns and Clinical Features in Adult-onset Subacute Sclerosing Panencephalitis: a Cross-sectional

Divyani Garg¹, Ayush Agarwal², Ashish Upadhyay²

¹All India Institute of Medical Sciences, New Delhi, India. divyanig@gmail.com.

Clinical Neuroradiology

|November 6, 2025

Summary

This summary is machine-generated.

Adult-onset subacute sclerosing panencephalitis (SSPE) frequently shows MRI abnormalities, including diffusion restriction. These neuroimaging findings are crucial for diagnosing and predicting outcomes in adult SSPE cases.

Keywords:

Adult DWI MRI Measles SSPE

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Area of Science:

Neurology
Radiology
Infectious Diseases

Background:

Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder resulting from persistent measles virus infection.
While traditionally a pediatric condition, adult-onset SSPE cases are increasingly recognized.
Radiological characteristics of adult-onset SSPE are not well-documented.

Purpose of the Study:

To characterize radiological abnormalities in adult-onset SSPE.
To investigate associations between clinical features and radiological findings in adult SSPE.
To enhance understanding of neuroimaging in adult SSPE for diagnosis and prognostication.

Main Methods:

A cross-sectional study included 53 patients with SSPE onset at age 18 years or older.
Clinical, demographic, laboratory, and MRI brain features were systematically recorded.
Statistical analyses were performed to explore clinico-radiological associations.

Main Results:

81.1% of patients exhibited MRI abnormalities, commonly involving white matter (subcortical and periventricular).
Parietal and frontal lobes were most frequently affected.
Diffusion restriction was observed in 23.3% of cases; various clinical symptoms correlated with specific MRI findings.

Conclusions:

MRI abnormalities are common in adult-onset SSPE, with diffusion restriction being more frequent than previously thought.
Neuroimaging plays a vital role in the diagnosis and prognostication of adult-onset SSPE.
Clinico-radiological correlations provide valuable insights into disease presentation and progression.