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Updated: Jan 12, 2026
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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
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Multiple circulating inflammatory proteins are associated with pathological lesions and kidney function decline in
Hiroki Kobayashi1, Yusuke Murata2, Yurie Akiya2
1Division of Nephrology, Hypertension, and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-chou, Itabashi-ku, Tokyo, 173-8610, Japan. kobayashi.hiroki@nihon-u.ac.jp.
Summary
Specific tumor necrosis factor (TNF) receptor-related proteins are elevated in Immunoglobulin A nephropathy (IgAN) and correlate with disease severity. These markers may help predict kidney function decline in IgAN patients.
Area of Science:
- Nephrology
- Immunology
- Biomarker Discovery
Background:
- The role of circulating inflammatory proteins in Immunoglobulin A nephropathy (IgAN) requires further clarification.
- Tumor necrosis factor (TNF) receptor-related markers are investigated for their association with IgAN severity and progression.
Purpose of the Study:
- To determine if serum inflammatory proteins, particularly TNF receptor markers, correlate with disease severity and progression in IgAN.
- To evaluate the potential of these proteins as predictors of kidney function decline in IgAN.
Main Methods:
- Serum levels of 10 inflammatory proteins were measured in 134 Japanese patients with newly diagnosed IgAN before kidney biopsy.
- Disease controls (membranous nephropathy, minimal change disease, lupus nephritis) and healthy controls were included for comparison.
- Associations between protein levels and clinical outcomes (kidney function, histological changes) were assessed.
Main Results:
- Elevated levels of TNF receptor-related proteins (TNF-R1, TNF-R2, TNF-R3, TNF-R7, TNF-R27) were observed in IgAN patients, correlating with tubulointerstitial lesion severity.
- TNF receptor proteins were also elevated in membranous nephropathy and lupus nephritis, but not in minimal change disease.
- TNF-R7 showed an early increase, and multivariable analysis indicated these proteins could predict kidney function decline.
Conclusions:
- Specific circulating inflammatory proteins, especially within the TNF receptor pathway, reflect disease activity and structural kidney injury in IgAN.
- These TNF receptor markers may serve as valuable biomarkers for identifying IgAN patients at higher risk of disease progression.
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