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Snakebite Induced Inflammation and Oxidative Stress in Children.

Kamirul Islam1, Manjur Hossain2, Nazima Khatun3

  • 1Department of Pediatrics, Burdwan Medical College, Burdwan, West Bengal, India.

Indian Pediatrics
|November 6, 2025
PubMed
Summary

Pediatric snakebites trigger significant inflammation and oxidative stress. Elevated C-reactive protein, interleukin-6, and malondialdehyde levels confirm this response in children following snakebite envenomation.

Keywords:
Oxidative damageReactive oxygen speciesSnake venomViperidae

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Area of Science:

  • Pediatric Toxicology
  • Biochemistry
  • Immunology

Background:

  • Snakebites are a significant health concern in children, often leading to complex physiological responses.
  • Understanding the inflammatory and oxidative stress markers associated with snakebites is crucial for effective management.

Purpose of the Study:

  • To investigate and compare the levels of inflammatory markers and oxidative stress indicators in children with snakebites versus healthy controls.
  • To establish a correlation between snakebite envenomation and the presence of inflammation and oxidative stress in pediatric patients.

Main Methods:

  • A case-control study design was employed, comparing 116 children with snakebites to 116 age-matched healthy controls.
  • Serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), and malondialdehyde (MDA) were measured and compared between the two groups.

Main Results:

  • Children with snakebites exhibited significantly higher median levels of serum C-reactive protein (11.1 mg/L vs 2.6 mg/L, P < 0.001).
  • Elevated serum interleukin-6 (84.8 pg/mL vs 15.2 pg/mL, P < 0.001) and malondialdehyde (1.4 nmol/mL vs 1.0 nmol/mL, P < 0.001) were also observed in the snakebite group.
  • These findings indicate a pronounced inflammatory and oxidative stress response in children following snakebites.

Conclusions:

  • Snakebite envenomation in children is strongly associated with significant systemic inflammation.
  • The study confirms that snakebites induce a notable increase in oxidative stress markers in the pediatric population.
  • These biochemical alterations highlight the severity of snakebite envenomation and suggest potential therapeutic targets.