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Updated: May 6, 2026
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
A curcumin-enabled ZIF8 nanosystem enables ovarian cancer treatment by inducing mitochondrial disruption
Zhishan Zhang1, Genghui Luo1, Xiaoxia Tang2
1Longdong Community Health Service, Longgang Center Hospital of Shenzhen, Shenzhen, China.
Abstract:
Ovarian cancer is a common malignancy affecting the female reproductive system. Curcumin (Cur) demonstrates potential as a treatment for ovarian cancer, but creating an effective curcumin-based drug delivery system remains challenging. The advent of the Zeolitic Imidazolate Framework (ZIF) system offers a novel approach for antitumor drug delivery. In this study, effective drug delivery to ovarian cancer cells was accomplished through the construction of a ZIF-based nanodrug delivery system, ZIF-Cur, that encapsulates curcumin. We verified that Cur delivered by ZIF enhanced mitochondrial ROS accumulation in tumor cells, thereby killing tumor cells. The system showed the well biosafety profile, offering a insight therapeutic perspective for ovarian cancer treatment.
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