Related Experiment Video
Updated: Jan 6, 2026
07:04
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
Published on: April 15, 2021
2.4K
Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection
Ahmad Nehme1, Liqi Shu2, Marion Boulanger1
1Neurology, Université Caen-Normandie, CHU de Caen-Normandie, Caen, France.
JAMA Network Open
|November 6, 2025
Summary
Fibromuscular dysplasia (FMD) is linked to a higher risk of recurrent spontaneous cervical artery dissection (SCEAD). Identifying FMD in SCEAD patients may aid in risk stratification and patient counseling for better outcomes.
Area of Science:
- Vascular Medicine
- Neurology
- Radiology
Background:
- Fibromuscular dysplasia (FMD) affects 6-14% of patients with spontaneous cervical artery dissection (SCEAD).
- The association between FMD and recurrent SCEAD requires further investigation.
Purpose of the Study:
- To identify clinical and radiological correlates of FMD in patients diagnosed with SCEAD.
- To determine if FMD is associated with an increased risk of recurrent SCEAD.
Main Methods:
- A retrospective cohort study (STOP-CAD) included 3714 adult patients with SCEAD from 63 sites across 16 countries (2015-2022).
- FMD was defined by history or imaging of cervical or renal arteries.
- Logistic regression and Cox proportional hazards models were used to analyze correlates and recurrent SCEAD rates.
Main Results:
- Of 3714 patients, 196 (5.3%) had FMD. FMD was associated with older age, female sex, noncervical dissection history, prior SCEAD, upper respiratory infection, cerebral aneurysm, and migraines.
- Patients with FMD were less likely to have single vertebral artery dissection or occlusive dissection.
- The 24-month risk of recurrent SCEAD was significantly higher in patients with FMD (7.7%) compared to those without (2.8%), with an adjusted hazard ratio of 2.75.
Conclusions:
- FMD in patients with SCEAD is associated with specific clinical and radiological characteristics.
- FMD significantly increases the risk of recurrent SCEAD, highlighting the importance of identifying FMD in these patients for risk assessment and management strategies.
Related Concept Videos
01:30Aneurysm I: Introduction
259
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
259
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
176
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
176
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
354
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
354
01:25Cardiomyopathy I: Introduction and Classification
465
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
465
01:30Atherosclerosis I: Introduction
738
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
738
01:18Disorders of the Autonomic Nervous System
1.4K
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
1.4K