The path to equitable respiratory syncytial virus prevention for infants: challenges and opportunities for global implementation
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View abstract on PubMed
Summary
This summary is machine-generated.Gavi
Area Of Science
- Global Health
- Immunology
- Pediatrics
Background
- Respiratory syncytial virus (RSV) significantly burdens infants globally, with 97% of mortality in low- and middle-income countries.
- High-income nations have introduced RSV prevention via maternal vaccination or monoclonal antibodies (mAbs) in infants, showing real-world effectiveness.
- Equitable access to RSV prevention remains a challenge, particularly in resource-limited settings.
Purpose Of The Study
- To review challenges and opportunities for expanding RSV prevention access for infants in resource-restricted settings.
- To align with WHO's Immunization Agenda 2030 and the UN's Leave No One Behind framework.
- To highlight urgent steps for global equitable access to RSV prevention.
Main Methods
- Review of current RSV burden, vaccine and mAb development, and health economics.
- Analysis of policy, implementation, programmatic considerations, surveillance, and awareness.
- Synthesis of recent research advances and future directions.
Main Results
- Maternal vaccination and infant mAbs demonstrate significant real-world effectiveness in reducing RSV-related illness and hospitalization.
- Despite global burden, RSV preventive strategies are largely absent in low- and middle-income countries.
- Gavi's approval of RSV maternal vaccination marks progress but requires further action for equitable access.
Conclusions
- Expanding access to RSV prevention in resource-limited settings is critical.
- A multi-faceted approach addressing burden, development, economics, policy, and implementation is needed.
- Urgent, coordinated action is required to ensure all infants worldwide benefit from RSV prevention.
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