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Exploring lipidomics in biomarker discovery.

M Malarvannan1, S Bhanu Teja Naik1, Navratan Soni1

  • 1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata, West Bengal 700054, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 6, 2025
PubMed
Summary

Lipidomics offers insights into lipid changes in health and disease, aiding biomarker discovery for conditions like diabetes and cancer. Challenges remain in clinical integration, but lipidomics holds promise for early diagnosis and targeted therapies.

Keywords:
Biomarker discoveryBiomarker validationLipidomicsMetabolic disorders

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Area of Science:

  • Systems biology
  • Biochemistry
  • Clinical diagnostics

Background:

  • Lipids are bioactive molecules regulating inflammation, metabolism, and signaling.
  • Lipidomics examines lipid species and their dynamic changes in health and disease.
  • Lipidomics is a powerful tool for identifying novel biomarkers in clinical settings.

Purpose of the Study:

  • To identify disease-specific lipid signatures and biomarkers across various conditions.
  • To examine the significance of lipidomics in clinical applications.
  • To discuss challenges and translational potential of lipidomics in clinical practice.

Main Methods:

  • In-depth summary of investigated lipidomic markers.
  • Comparative analysis of lipidomics methodologies.
  • Discussion of lipidomic biomarker validation processes.

Main Results:

  • Lipidomics has identified potential biomarkers for metabolic, cardiovascular, neurodegenerative, cancer, and inflammatory disorders.
  • Significant advancements in understanding lipid roles in disease.
  • Identified challenges hindering routine clinical integration.

Conclusions:

  • Lipidomics-driven biomarker discovery bridges lipid research and clinical applications.
  • Lipidomics shows promise for risk assessment, early diagnosis, and targeted therapy.
  • Further research and validation are needed for routine clinical translation.