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Serum proteomic analysis in equine obstructive colic: A prospective observational study.

Maria Chiara Alterisio1, Ilaria Iacobucci2, Jacopo Guccione1

  • 1Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Delpino 1, Naples 80137, Italy.

Veterinary Journal (London, England : 1997)
|November 6, 2025
PubMed
Summary

Proteomic analysis identified key protein changes in horses with obstructive colic, revealing immune response, blood coagulation, and lipid metabolism alterations. These findings offer potential biomarkers for early diagnosis of equine intestinal disease.

Keywords:
BiomarkersColicHealthHorsesProteomic

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Area of Science:

  • Veterinary Medicine
  • Proteomics
  • Biochemistry

Background:

  • Equine obstructive intestinal colic is a significant cause of morbidity and mortality.
  • Early diagnosis and understanding the pathological process are crucial for effective treatment.

Purpose of the Study:

  • To identify serum proteomic signatures in horses with obstructive colic.
  • To characterize the pathological mechanisms involved.
  • To assess potential protein biomarkers for early diagnosis.

Main Methods:

  • Serum samples were collected from seven horses with obstructive colic at admission and upon recovery.
  • Standard hematobiochemical, inflammatory, and lipid profiles were analyzed.
  • Proteomic profiling was performed using a within-group analysis, with validation by Multiple Reaction Monitoring.

Main Results:

  • Seventy proteins showed significant expression differences between admission and recovery states.
  • Altered proteins were primarily involved in immune response (e.g., HPX, C2, CFB), blood coagulation (e.g., KNG1, VWF, F13A1), and lipid homeostasis (e.g., APOA4, APOE, LCAT).
  • The results suggest an inflammatory status, potential bacterial triggers, and hyperlipidemia in affected horses.

Conclusions:

  • Obstructive colic in horses is associated with complex proteomic alterations.
  • Immune response, coagulation, and lipid metabolism pathways are significantly impacted.
  • Identified proteins represent potential biomarkers for early detection and therapeutic monitoring of equine colic.