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Pretargeted Immuno-PET Enables Monoclonal Antibody Imaging Beyond the Blood-Brain Barrier

Tobias Gustavsson1, Thomas Kustermann2, Lars Hvass3,4

  • 1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

Molecular Pharmaceutics
|November 6, 2025
PubMed

Keywords:
Imaging CNSblood−brain barrierpretargetingtetrazine ligationtransferrin receptor

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Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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