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Updated: Jan 12, 2026

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
Published on: February 20, 2017
Prevalence and assessment of exercise-induced desaturation in lymphangioleiomyomatosis
Jan Johnson1, Simon R Johnson2
1Centre for Respiratory Research, Translational Medical Sciences, School of Medicine, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, UK.
Abstract:
Exercise-induced desaturation is poorly recognised in lymphangioleiomyomatosis (LAM) and its relationship to outcome is unknown. In a UK cohort study, 37% of 131 women with LAM experienced exercise-induced desaturation to <88% during a 6 min walk test. Forced expiratory volume in 1 s (FEV1) and DLCO were associated with walk parameters but had poor predictive accuracy for exercise-induced desaturation. A 5-year follow-up showed exercise-induced desaturation at baseline was associated with rapid FEV1 decline (p=0.008) and need for rapamycin treatment (p=0.00001). Women with LAM should be evaluated for exercise-induced desaturation to target ambulatory oxygen and improve identification of those at risk of poor outcomes.
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Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...

