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Patient safety in AI-powered diagnostic pathology.

Massimo Rugge1, Matteo Fraschini2, Enrico Orvieto3

  • 1DIMED, Università degli Studi di Padova, Padova, Italy massimo.rugge@unipd.it.

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|November 6, 2025
PubMed
Summary
This summary is machine-generated.

Artificial intelligence (AI) enhances diagnostic pathology accuracy but cannot replace human oversight. Implementing AI requires clear application domains and robust safety measures for patient well-being.

Keywords:
Artificial IntelligenceDiagnostic Techniques and ProceduresPatient SafetySAFETY

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Area of Science:

  • Pathology
  • Medical Informatics
  • Artificial Intelligence

Background:

  • Diagnostic pathology integrates traditional histology with artificial intelligence (AI) for enhanced accuracy.
  • AI in pathology involves digital image generation, algorithm training, dataset construction, validation, and output monitoring.
  • Current evidence indicates AI complements, but does not autonomously replace, human diagnostic capabilities.

Purpose of the Study:

  • To critically review current AI applications in diagnostic pathology.
  • To emphasize patient-centered safety considerations in AI implementation.
  • To highlight the need for collaborative regulatory measures for AI in pathology.

Main Methods:

  • Review of current scientific evidence on AI in diagnostic pathology.
  • Analysis of key steps in AI-powered diagnostic pathology workflow.
  • Examination of international healthcare recommendations for AI implementation.

Main Results:

  • AI can improve diagnostic accuracy but requires human supervision.
  • Generative intelligence presents new opportunities in pathology.
  • Clear definition of application domains and safety monitoring are crucial for clinical AI use.

Conclusions:

  • Patient safety is paramount in AI-powered diagnostic pathology.
  • Collaborative efforts are essential for developing safety-oriented regulatory measures.
  • International cooperation among stakeholders is necessary for responsible AI deployment in pathology.