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Updated: Jan 12, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
Published on: May 2, 2025
Emerging interventional treatments in the management of pediatric brain tumors
Margaret Shatara1, Winson S Ho2, Jarod L Roland3
1Department of Pediatric Hematology and Oncology, Pediatric Neuro-Oncology Program, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, United States.
Abstract:
Recent advancements in the molecular understanding of pediatric brain tumor biology have significantly contributed to the development of innovative therapeutic strategies aimed at improving clinical outcomes for affected children. These scientific breakthroughs have facilitated the identification of specific molecular targets and signaling pathways integral to the oncogenesis of pediatric brain tumors, thereby enabling the design of targeted therapies that disrupt these pathogenic processes. Furthermore, the incorporation of immunotherapy and precision medicine approaches has unveiled novel therapeutic avenues, offering the potential for more efficacious and less toxic treatment modalities. As research in this domain continues to progress, these cutting-edge therapeutic interventions are anticipated to enhance survival rates and improve the quality of life for pediatric patients. This review delineates emerging interventional treatments in pediatric brain tumor management and examines the persistent challenges within the field.

