Preoperative logGAR Predicts Postoperative Complications in Pediatric Cardiac Surgery: A Retrospective Cohort Study
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View abstract on PubMed
Summary
This summary is machine-generated.The preoperative gamma-glutamyl transferase-to-albumin ratio (logGAR) can predict anesthesia-related complications in children undergoing congenital heart disease (CHD) surgery. Higher logGAR levels indicate increased risk for adverse outcomes like prolonged ventilation and ICU stay.
Area Of Science
- Pediatric Anesthesiology
- Cardiovascular Surgery
- Biomarker Research
Background
- Anesthesia-related complications are a significant concern in pediatric congenital heart disease (CHD) surgery.
- Prolonged mechanical ventilation, reintubation, and extended ICU stays are common adverse events.
- Identifying predictive markers for these complications is crucial for improving patient outcomes.
Purpose Of The Study
- To evaluate the preoperative gamma-glutamyl transferase-to-albumin ratio (logGAR) as a predictor of anesthesia-related complications in pediatric CHD patients.
- To assess the association between logGAR, reflecting oxidative stress, inflammation, and nutritional status, and postoperative complications.
Main Methods
- Retrospective cohort study including 942 pediatric patients undergoing cardiopulmonary bypass for CHD (2018-2024).
- Calculation of preoperative logGAR.
- Analysis of primary outcomes: mechanical ventilation ≥72 hours, reintubation within 48 hours, ICU length of stay >90th percentile, or mortality.
Main Results
- 17.4% of patients (164/942) experienced complications.
- Preoperative logGAR was significantly higher in patients with complications (median -0.97 vs. -1.32, p < 0.001).
- Each unit increase in logGAR correlated with increased complication risk (aOR 2.41; 95% CI 1.49-3.95), with the strongest association observed between -1.62 and 0.467.
Conclusions
- Preoperative logGAR is a significant predictor of anesthesia-related complications following pediatric CHD surgery.
- Incorporating logGAR into preanesthetic evaluations may enhance perioperative risk stratification for these vulnerable patients.
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