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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
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Predictors of antiviral treatment in Chronic Hepatitis -B (CHB) population

Tanu Yadav1, Suchit Swaroop1

  • 1Experimental and Public Health Laboratory, Department of Zoology, University of Lucknow, Lucknow, U.P. India.

Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology
|November 6, 2025
PubMed

Insights

This study investigated Hepatitis B Virus (HBV) biomarkers in Chronic Hepatitis B (CHB) patients. Results show HBeAg is significantly associated with antiviral therapy, guiding treatment decisions for HBsAg-positive individuals.

Area of Science:

  • Hepatology
  • Virology
  • Clinical Biochemistry

Background:

  • Chronic Hepatitis B (CHB) is a liver condition managed with antiviral drugs.
  • Hepatitis B Virus (HBV) DNA, liver enzymes, HBeAg, and HBeAb are key indicators for CHB treatment decisions.

Purpose of the Study:

  • To determine the prognostic value of Hepatitis B envelope antibody (HBeAb) in CHB infection.
  • To explore the relationship between HB viral antigens, HB antibodies, and liver enzymes in CHB patient treatment.

Main Methods:

  • Study included all Hepatitis B surface Antigen (HBsAg)-positive patients.
  • Data extraction focused on biochemical markers relevant to antiviral therapy.

Main Results:

  • An association was found between antiviral drugs and viral antigens.
  • HBeAg showed a significant association with antiviral therapy (p=0.022).
  • Highest HBeAg positivity occurred in the 15-30 year age group.

Conclusions:

  • Biomarkers are crucial for managing HBsAg-positive patients.
  • The study provides insights for incorporating specific indicators into HBV treatment protocols.
Abstract

Keywords:
AntiviralHBV-DNA (viral load)HBeAbHBeAgliver enzymes (AST and ALT)

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