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Published on: December 22, 2020
Nanobodies: a new paradigm for brain disorder therapies
Pierre-André Lafon1, Laurent Prézeau1, Jean-Philippe Pin1
1Institut de Génomique Fonctionnelle (IGF), University of Montpellier, CNRS, INSERM, 34094 Montpellier Cedex 5, France.
Abstract:
Camelid-derived nanobodies offer a promising alternative to conventional antibodies for the treatment of brain disorders. Their current development in models of schizophrenia or Alzheimer's disease highlights their strong therapeutic potential. Optimizing their delivery and ensuring their safety are major challenges, but their modularity and low immunogenicity make them promising candidates for neurotherapy.
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