ResNet-EfficientNet powered framework for high-precision cough-based classification of infectious diseases
Dhana Sony Johnson1, Paramasivam Alagumariappan2, Malathy Sathyamoorthy3
1Department of Biomedical Engineering, Vel Tech Rangarajan Dr. Sagunthala R&D Institute of Science and Technology, Chennai, India.
Scientific Reports
|November 6, 2025
Summary
A novel deep learning framework effectively classifies COVID-19 using cough sounds. The ResNet model achieved 98.5% accuracy, enabling early diagnosis and reduced transmission of the SARS-CoV-2 virus.
Area of Science:
- * Medical Diagnostics
- * Artificial Intelligence in Healthcare
- * Respiratory Illnesses
Background:
- * COVID-19, caused by SARS-CoV-2, is a highly contagious respiratory illness that emerged in late 2019, causing global health and economic challenges.
- * Rapid diagnosis of COVID-19 is crucial for controlling transmission and managing patient care, similar to other infectious diseases.
- * Transmission occurs via respiratory droplets, highlighting the need for efficient diagnostic tools.
Purpose of the Study:
- * To propose a deep learning framework for classifying COVID-19 using cough sounds.
- * To evaluate the performance of various deep learning models, including 1D-CNN, DS-CNN, EfficientNet v2, and ResNet, for COVID-19 detection via cough analysis.
- * To identify the most effective model for accurate and rapid COVID-19 diagnosis based on cough acoustics.
Main Methods:
- * Development of a deep learning framework for analyzing cough sounds.
- * Implementation and comparison of multiple deep learning architectures: 1D-CNN, DS-CNN, EfficientNet v2, and ResNet.
- * Performance evaluation using key metrics: accuracy, precision, recall, F1-Score, Matthews Correlation Coefficient (MCC), and False Positive Rate (FPR).
Main Results:
- * Pre-trained models, specifically EfficientNet v2 and ResNet, demonstrated superior performance compared to other deep learning models.
- * The ResNet model achieved exceptional results with 98.5% accuracy, 98.99% precision, 98% recall, a 0.9849 F1-Score, a 0.9699 MCC, and a 0.01 FPR.
- * These findings indicate ResNet's superiority in classifying COVID-19 positive cough sounds.
Conclusions:
- * The proposed deep learning framework, particularly using the ResNet model, offers a highly accurate method for COVID-19 classification via cough sounds.
- * This approach facilitates early intervention, enabling physicians to isolate or treat patients promptly and reduce disease transmission.
- * Cough sound analysis using advanced AI presents a promising, non-invasive tool for widespread COVID-19 screening and management.
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