Photon density wave spectroscopy as process analytical technology: a review of recent advances in technology and
Thomas Schiewe1, Aaron Justin Koenig2,3, Björn Weiske4
1Chair of Bioprocess Engineering, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany. schiewe@campus.tu-berlin.de.
Abstract:
Photon density wave (PDW) spectroscopy is a calibration-free method for the simultaneous, absolute, and independent quantification of the optical absorption coefficient and the reduced scattering coefficient of highly light scattering materials. It allows for dilution-free particle sizing in concentrated liquid systems. Thus, it is beneficial as an inline process analytical technology (PAT). A brief comparison to other particle sizing technologies, the theoretical background of PDW spectroscopy, the current technical status, and limitations and technical challenges are reviewed. In addition, a comparative overview of the recent applications of PDW spectroscopy as PAT for chemical, biotechnological, and food processing is provided.
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