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Endocan levels in patients with hyperprolactinemia.
Aykut Hacıömeroğlu1, Aşkın Güngüneş2, Selim Yalçın3
1Department of Internal Medicine, Faculty of Medicine, Kırıkkale University, Kırıkkale, Türkiye. aykuthaciomeroglu1@gmail.com.
BMC Endocrine Disorders
|November 6, 2025
Summary
Elevated prolactin levels may indicate higher cardiovascular risk. This study found higher Endocan levels in hyperprolactinemia patients, suggesting a link to endothelial dysfunction and increased cardiovascular risk.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Biochemistry
Background:
- Elevated prolactin is linked to increased cardiovascular risk.
- Endocan's role in hyperprolactinemia-associated cardiovascular risk is not well understood.
Purpose of the Study:
- To investigate the association between Endocan levels and cardiovascular risk in patients with hyperprolactinemia.
- To compare Endocan levels in hyperprolactinemic patients versus healthy controls.
Main Methods:
- 39 hyperprolactinemic patients and 39 healthy controls were recruited.
- Cardiovascular risk parameters (BMI, lipids, CRP) and serum Endocan levels (ELISA) were measured.
- Statistical analyses were performed to compare groups and assess correlations.
Main Results:
- Serum Endocan levels were significantly higher in the hyperprolactinemia group (p=0.028).
- Endocan levels correlated positively with waist circumference, body weight, and BMI in hyperprolactinemic patients.
- No significant differences in BMI, lipid profile, CRP, or other metabolic markers were observed between groups.
Conclusions:
- Elevated Endocan levels in hyperprolactinemia suggest a potential role in endothelial dysfunction and increased cardiovascular risk.
- Further research with larger cohorts is warranted to confirm these findings.
- Endocan may serve as a biomarker for cardiovascular risk in hyperprolactinemia.
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