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Effect of creatine supplementation on kidney function: a systematic review and meta-analysis

Elham Kabiri Naeini1, Milad Eskandari2, Mojgan Mortazavi1

  • 1Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

BMC Nephrology
|November 6, 2025
PubMed
Summary

Creatine supplementation causes a small, temporary rise in serum creatinine, not kidney damage. Glomerular filtration rate (GFR) remains unaffected, indicating safe kidney function in users.

Keywords:
Creatine supplementationGlomerular filtration rateKidney functionMeta-analysisRenal safetySerum creatinine

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