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Will large language models transform clinical prediction?

Yusuf Yildiz1, Goran Nenadic2, Meghna Jani3

  • 1Faculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK. yusuf.yildiz@postgrad.manchester.ac.uk.

Diagnostic and Prognostic Research
|November 6, 2025
PubMed
Summary

Large language models (LLMs) show potential for improving clinical prediction models using electronic health records. However, challenges in methodology, validation, infrastructure, and regulation must be addressed for effective healthcare integration.

Keywords:
BiasClinical prediction modelsFairnessLarge language modelsRegulation and reporting

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