Analysis of burden of liver cancer by GBD 2021

This study used the Global Burden of Disease (GBD) 2021 database to analyze and summarize the global disease burden and changing trends of liver cancer, which has strong public health reference value.

The data for this study is drawn from the GBD 2021 study. In the analysis, we conducted a detailed stratification based on gender, 20 age groups, 21 GBD regions, 204 countries and territories, and 5 SDI quintiles. This study aims to explore the liver cancer burden of age-standardized prevalence rates (ASPR), incidence rates, death rates (ASMR), and disability-adjusted life years (ASDR).

In 2021, liver cancer continued to impose a substantial global burden. Although the global burden of liver cancer is declining overall, there are marked regional differences in the scale of reduction. Incidence of liver cancer varies markedly across regions and sexes within each age group, with older people bearing a disproportionately high burden, especially among males in high SDI regions and low-middle SDI regions. The declining global incidence of liver cancer among both genders from 2022 to 2040.

These patterns highlighted the necessity for focused public health measures and management plans to tackle the inequalities in liver cancer.